Joung et al reported that MSM could enhance growth hormone (GH) signaling and osteogenic differentiation of bone marrow mesenchymal stem cells (MSCs). 12 It demonstrated that MSM was able to protect articular cartilage in patients with osteoarthritis. 9–11 It was reported that co-incubation of MSM and human chondrocytes in moderate severity osteoarthritis could inactive the coding of genes for manufacturing pro-inflammatory cytokines.
Methylsulfonylmethane (MSM, (CH 3) 2SO 2) is an organosulfur compound that can maintain the connective tissues in the human body benefitting from its sulfur content. 5 On the contrary, small molecule drugs with distinctive bioactivity are valuable for bio-functionalized polymeric tissue engineering scaffolds owing to their stability and easy processability with polymers. 3, 4 A second disadvantage of the growth factors is that the short half-life and unstable characteristic makes them difficult to be delivered within polymer scaffolds. However, one major disadvantage is that most of them are expensive and can induce cancers. 1, 2 Growth factors have shown favorable function to regenerate bone tissue through regulating cell proliferation, differentiation as well as the formation of mineralized tissue.
Keywords: biopolymer, scaffold, drug delivery, sustained release, osteogenesisīone tissue engineering aims to develop highly porous scaffolds with proper bioactivity to facilitate new bone formation. In vivo bone formation ability was significantly enhanced for 1% MSM/HA/PLGA scaffolds indicated by the repair of rabbit radius defects which might be affected by a stimulated release of MSM by enzyme systems in vivo.ĭiscussion: Finding from this study revealed that the incorporation of MSM would be effective in improving the osteogenesis activity of the HA/PLGA porous scaffolds. Cell viability, proliferation, and alkaline phosphatase (ALP) activity were significantly promoted by incorporating 0.1% of MSM in the scaffolds. Results: Sustained release of MSM from the scaffolds was observed, and the total MSM release from 1% and 10% MSM/HA/PLGA scaffolds within 16 days was up to 64.9% and 68.2%, respectively. MSM loading efficiency, in vitro drug release as well as the biological activity of MSM-loaded scaffolds were investigated by incubating mouse pre-osteoblasts (MC3T3-E1) in the uniform and interconnected porous scaffolds. Methods: Three-dimensional (3D) hydroxyapatite/poly (lactide- co-glycolide) (HA/PLGA) porous scaffolds with different doping levels of MSM were prepared using the phase separation method. However, it is rarely used in developing bioactive scaffolds in bone tissue engineering. Introduction: As a popular dietary supplement containing sulfur compound, methylsulfonylmethane (MSM) has been widely used as an alternative oral medicine to relieve joint pain, reduce inflammation and promote collagen protein synthesis. Yueming Guo, 1 Pengpeng Li, 2, 3 Zongliang Wang, 4 Peibiao Zhang, 4 Xiaodong Wu 2ġDepartment of Orthopaedics, Foshan Hospital of Traditional Chinese Medicine, Foshan, 528000, People’s Republic of China 2Xuzhou Central Hospital, Xuzhou, 221009, People’s Republic of China 3Graduate School of Bengbu Medical College, Bengbu, 233030, People’s Republic of China 4Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, People’s Republic of ChinaĬorrespondence: Xiaodong Wu Peibiao Zhang, Email
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